A surprising new role for ApoE offers explanation for its diverse range of effects, particularly in Alzheimer's

Apolipoprotein E enters the nucleus and binds to promoter region of 1700 genes, report scientists. Seventy-five million Americans are ApoE4 carriers, putting them at increased risk for Alzheimer's disease, and another 7 million carry two copies of ApoE4, giving them an even higher, 10 -- 12 fold increased risk of developing Alzheimer's.